ABSTRACT
The development of highly sensitive and rapid biosensing tools targeted to the highly contagious virus SARS-CoV-2 is critical to tackling the COVID-19 pandemic. Quantum sensors can play an important role because of their superior sensitivity and fast improvements in recent years. Here we propose a molecular transducer designed for nitrogen-vacancy (NV) centers in nanodiamonds, translating the presence of SARS-CoV-2 RNA into an unambiguous magnetic noise signal that can be optically read out. We evaluate the performance of the hybrid sensor, including its sensitivity and false negative rate, and compare it to widespread diagnostic methods. The proposed method is fast and promises to reach a sensitivity down to a few hundreds of RNA copies with false negative rate less than 1%. The proposed hybrid sensor can be further implemented with different solid-state defects and substrates, generalized to diagnose other RNA viruses, and integrated with CRISPR technology.